Application of Supercritical Fluid ‎Technology for Preparation of Drug Loaded ‎Solid Lipid Nanoparticles

Authors

A. Golestani Department of Biochemistry, Faculty of medicine, Tehran University of Medical Sciences, ‎Tehran, Iran.‎

J. Karimi-Sabet JaberEbneHayyan National Research Laboratory, NSTRI, Tehran, Iran.‎

M. Amanlou Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical ‎Sciences, Tehran, Iran. ‎

M. Shariaty Niassar Department of Chemical Engineering, Faculty of Engineering, University of Tehran, Tehran, ‎Iran. ‎

Z. Akbari Department of Chemical Engineering, Faculty of Engineering, University of Tehran, Tehran, ‎Iran. ‎

Abstract:

Small changes in pressure or temperature, close to the critical point, lead to large changes in solubility of supercritical carbon dioxide (CO2). Environmentally friendly supercritical CO2 is the most popular and inexpensive solvent which has been used for preparation of nanodrugs and nanocarriers in drug delivery system with supercritical fluid technology. Delivery of a drug is one of the most challenging research areas in pharmaceutical sciences. With a combination of drugs and innovative delivery systems such as lipid nanocarriers, drugs efficiency and safety have been improved significantly. There are various techniques available to produce drug loaded solid lipid nanoparticles. Among them, supercritical fluid technology has been identified as potentially effective and applicable approach which has attracted increasing attention during recent years. This technique has several advantages such as avoid the use of solvents, particles are obtained as a dry powder, instead of suspensions, mild pressure and temperature conditions can be applied. Nevertheless, little attention has been paid to formation of drug loaded solid lipid nanoparticles by supercritical fluid technology. In this paper, we present a brief introduction to solid lipid nanocarriers. Then a general overview of different processes of supercritical fluid technology has been provided and also case studies are presented to show the potential benefits of this approach in drug loaded solid lipid nanoparticle production.

Upgrade to premium to download articles

Already have an account?login

similar resources

preparation and stability evaluation of urea-loaded solid lipid nanoparticles for topical application.

full text

Preparation and characterization of solid lipid nanoparticles loaded with doxorubicin.

Solid lipid nanoparticles (SLN) loaded with doxorubicin were prepared by solvent emulsification-diffusion method. Glyceryl caprate (Capmul)MCM C10) was used as lipid core, and curdlan as the shell material. Dimethyl sulfoxide (DMSO) was used to dissolve both lipid and drug. Polyethylene glycol 660 hydroxystearate (Solutol)HS15) was employed as surfactant. Major formulation parameters were optim...

full text

Preparation, characterization, and optimization of primaquine-loaded solid lipid nanoparticles

Primaquine (PQ) is one of the most widely used antimalarial drugs and is the only available drug that combats the relapsing form of malaria. PQ use in higher doses is limited by severe tissue toxicity including hematological- and gastrointestinal-related side effects. Nanoformulation of drugs in an appropriate drug carrier system has been extensively studied and shown to have the potential to i...

full text

Preparation and Evaluation of Montelukast Sodium Loaded Solid Lipid Nanoparticles

Solid lipid nanoparticles (SLNs) are an alternative carrier system used to load the drug for targeting, to improve the bioavailability by increasing its solubility, and protecting the drug from presystemic metabolism. The avoidance of presystemic metabolism is due to the nano-metric size range, so that the liver cannot uptake the drug from the delivery system and is not metabolized by the liver...

full text